The reason CV's get sunk by 4E bombers is because you can attack with huge formations of bombers early. I strongly expect that 100 heavy bombers converging on a CV TF would score some hits as in the game.
Actually, it's a bit of a crap-shoot. Sorry to drag my PBEM opponnets into it, but
my own experience in PBEM is what I will offer. Disclaimer : Results not guarenteed and may vary by customer.
In my game vs. Erstad, I had about 120 B-17s (unescorted) launch vs. four CVs of KB
in July 1942 (who is still on the offensive by the way). I lost about 40 destroyed, probably 50 damaged. I shot down down about 20 Zeros. About 40 actually made attacks at 6000', and zero hits. The upside is, I'll take 30 dead elite Zero pilots, and I'm sure I made Erstad crap his pants. And this launch
was the first launch of 4e bombers vs. KB of the entire game.
In my game vs. Parker (02-42), I had a single sqdn (16) of B-17s escorted by 24 P-40Bs launch vs. all 6 units of KB. The P40s were thrahsed, and I probably lost 5 B-17s, and 5 damages. I scored one ping-pong on the Haruana.
A second time in my game vs. Parker, I had about 20 B-17s launch at 6000', escorted by about 20 RDAF suicide fighters, vs. Hiryu and Soryu. I lost about 8 B-17s (plus all the RDAF fighters, don't care). I shot down about 5 Zeros, and scored a hit on each of Hiryu and Soryu.
Don't know the extent of the damage tho, since we had a replay bug that turn, and I never got to see the attack (going by the combat reports he sent). I think I might have hurt Soryu, but I know Hiryu is still in the area and launching strikes.
(* shrug *)
In my two single games, those are the only times that my B-17s have ever launched vs. KB.
My team game (06-42), I'm not in charge of the B-17s (Knavey is), but I don't think they've ever launched vs. KB.
I can't offer more examples, because there aren't any. Party because my opponents are smart enough to stay clear of AF(6) bases, and partly because it really, REALLY, tough to get them to launch in the first place.
-F-