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'Key nose cells identified as likely COVID-19 virus entry points' https://www.sciencedaily.com/releases/2 ... 130420.htm

Human Cell Atlas study could help understand transmission of the virus

Two specific nose cell types have been identified as likely initial infection points for COVID-19 coronavirus. Scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that the COVID-19 virus uses to get into our cells, which could help explain the high rate of transmission. The study with Human Cell Atlas Lung Biological Network found cells in the eye and some other organs also contain the viral-entry proteins...

Based on this, it would appear that cutting off your nose greatly reduces the chance of catching Covid-19. [:D]

ORIGINAL: HansBolter

The Big Three you mention were things that could be dealt with in a direct manner.
There has been a concerted world wide effort to find a cure for cancer for almost the entirety of my lifetime with no success yet.
I don't think (and I am not a medical professional) that fighting diseases is quite as direct a process as the referenced Big Three.

Let's look at a single statistic: in general, cancer in children and teenagers is very uncommon, accounting for less than 1% of total cases, yet, the money devoted to fighting pediatric cancer is 4% - from six to eight times the problem's dimension. You will not find this disparity in other kind of cancer research. Cancer in children and kids sux painfully and we react accordingly to this: emotionally, not proportionally.

And yet, for all his being bad, painful and sad, cancer never, literally, stopped the natural flow of life on the whole planet by just snapping its fingers (Thanos-like). This virus did. What I do expect is at the very least a proportional long term effort for this to be flat out stopped from happening again.

Yes, I changed the red button back to green.

Be warned: the contents will not change. [:)]

ORIGINAL: MakeeLearn

ORIGINAL: MakeeLearn

Cuomo Says 21 Percent of Those Tested in N.Y.C. Had Virus Antibodies
Apr 23, 2020

https://www.nytimes.com/2020/04/23/nyre ... pdate.html

"About 21 percent of roughly 1,300 people in New York City who were tested for coronavirus antibodies this week tested positive, Gov. Andrew M. Cuomo said on Thursday.

The results come from a state program that randomly tested 3,000 supermarket customers across New York State. Nearly 14 percent of those tests came back positive, Mr. Cuomo said.

If those numbers translate to the true incidence of coronavirus, they would mean that more than 1.7 million people in New York City, and more than 2.6 million people statewide, have already been infected.

These numbers are far greater than the 250,000 confirmed cases of the virus itself that the state has recorded.

They would also mean that the fatality rate from the virus is relatively low — about 0.5 percent, Mr. Cuomo said."

No comments???????????????????

This goes along with the studies coming out of California.

Still reading. Keep posting!

You're dredging up some great stuff. This is added to my other bookmarks on serology tests, cruise ship studies and military ship studies.

This is a surprise.

Navy leaders recommend reinstating the Roosevelt captain fired over a virus warning.

Capt. Brett E. Crozier should be restored to command of the aircraft carrier Theodore Roosevelt, the Navy’s top officials recommended on Friday.
But Defense Secretary Mark T. Esper, who was briefed on the recommendations, has asked for more time to consider whether he will sign off on the reinstatement of the captain of the nuclear-powered carrier.

A reinstatement of Captain Crozier would be a stunning turnaround in a story that has seized the attention of the Navy, the overall military and even a nation grappling with the coronavirus. From the moment that his letter pleading for help from Navy officials first became public, Captain Crozier has taken on the role of an unlikely hero, willing to risk his career for the sake of his sailors.

https://www.nytimes.com/2020/04/24/us/c ... k-4f099d98

ORIGINAL: RFalvo69

Be warned: the contents will not change. [:)]

According to Bill Dolson it will or you will be the one to get the thread locked.

Sorry you missed my point.

It wasn't that the effort won't be made...it was not to be expectant of results.

Random testing advocated to help define opening measures after lockdowns.

We are flying blind in the fight against Covid-19. The number of cases is surely much greater than what we see and what is being relied on to provide direction for devising and implementing policy.

But is the true number two to three times higher, as some experts say? More like 10 times, as other analysts calculate? Or perhaps as much as 50 to 100 times higher, as indicated by early random testing in Iceland; a population study of Vò, Italy; and some recent results in California?

The recent Nobel in economic science went to Abhijit Banerjee, Esther Duflo and Michael Kremer, researchers using random control trials, the mainstay of scientific medicine. Their work dramatizes how misleading it can be, for example, to measure disease prevalence by reference to those who seek treatment at rural health clinics, omitting the multitudes who have no access.

Local random tests should be undertaken immediately. University researchers, working with local governments or operating independently, could conduct simple randomization, testing perhaps 5,000 or 10,000 individuals. We would quickly learn whether total cases were five times or 50 times current estimates in those areas.

https://www.nytimes.com/2020/04/24/opin ... Multimedia

In the article that I posted about Dr. Fauci, it discussed both a universal influenza vaccine as well as a universal corona vaccine. Maybe this will be the impetus to develop those vaccines.

There are treatments for cancer, especially if the look at older drugs like antabuse which has been known to kill cancers cells.

That US Navy Captain should not be reinstated. Because of his letter, it became known that the USS Rooseveldt could not be deployed. The Chinese government is now conducting naval operations with no US carrier battle group able to respond. It also pins the USS Roosevelt to a specific place. How is that for operational security? Loose lips sink ships.

ORIGINAL: HansBolter

ORIGINAL: RFalvo69

Be warned: the contents will not change. [:)]

According to Bill Dolson it will or you will be the one to get the thread locked.

Sorry you missed my point.

It wasn't that the effort won't be made...it was not to be expectant of results.

Yes Hans, because your behaviour has been above reproach this entire thread [8|]

ORIGINAL: obvert

Random testing advocated to help define opening measures after lockdowns.

We are flying blind in the fight against Covid-19. The number of cases is surely much greater than what we see and what is being relied on to provide direction for devising and implementing policy.

But is the true number two to three times higher, as some experts say? More like 10 times, as other analysts calculate? Or perhaps as much as 50 to 100 times higher, as indicated by early random testing in Iceland; a population study of Vò, Italy; and some recent results in California?

The recent Nobel in economic science went to Abhijit Banerjee, Esther Duflo and Michael Kremer, researchers using random control trials, the mainstay of scientific medicine. Their work dramatizes how misleading it can be, for example, to measure disease prevalence by reference to those who seek treatment at rural health clinics, omitting the multitudes who have no access.

Local random tests should be undertaken immediately. University researchers, working with local governments or operating independently, could conduct simple randomization, testing perhaps 5,000 or 10,000 individuals. We would quickly learn whether total cases were five times or 50 times current estimates in those areas.

https://www.nytimes.com/2020/04/24/opin ... Multimedia

I had a discussion with a fellow analyst at work (before this really kicked off) where they suggested that instead of contact tracing or in-hospital testing, all effort should have went in to random sampling nationwide. Their point was that it would probably give a better idea of actual incidence that the current methods.

ORIGINAL: RangerJoe

That US Navy Captain should not be reinstated. Because of his letter, it became known that the USS Rooseveldt could not be deployed. The Chinese government is now conducting naval operations with no US carrier battle group able to respond. It also pins the USS Roosevelt to a specific place. How is that for operational security? Loose lips sink ships.

I was very surprised to see this news. Might be something we don't know going on there.

ORIGINAL: obvert

This is a surprise.

Navy leaders recommend reinstating the Roosevelt captain fired over a virus warning.

Capt. Brett E. Crozier should be restored to command of the aircraft carrier Theodore Roosevelt, the Navy’s top officials recommended on Friday.
But Defense Secretary Mark T. Esper, who was briefed on the recommendations, has asked for more time to consider whether he will sign off on the reinstatement of the captain of the nuclear-powered carrier.

A reinstatement of Captain Crozier would be a stunning turnaround in a story that has seized the attention of the Navy, the overall military and even a nation grappling with the coronavirus. From the moment that his letter pleading for help from Navy officials first became public, Captain Crozier has taken on the role of an unlikely hero, willing to risk his career for the sake of his sailors.

https://www.nytimes.com/2020/04/24/us/c ... k-4f099d98

Can't say I'm entirely surprised, the entire thing was utterly mishandled.

ORIGINAL: RangerJoe

That US Navy Captain should not be reinstated. Because of his letter, it became known that the USS Rooseveldt could not be deployed. The Chinese government is now conducting naval operations with no US carrier battle group able to respond. It also pins the USS Roosevelt to a specific place. How is that for operational security? Loose lips sink ships.

The alternative being to leave a nuclear powered carrier at sea while it's most valuable assets (the sailors) are crippled with a virus?

That will really scare the Chinese.

It's things like this that cause serious accidents on warships, and I know the USN prides itself on avoiding being associated with the floating tinderboxes that some other navies field.

One can only hope MM isn't too dense to understand that I have him blocked.

ORIGINAL: HansBolter

One can only hope MM isn't too dense to understand that I have him blocked.

That's terribly like the snowflakes you so detest, Hans!

I expected better!

EDIT: Actually, that's not true - I didn't.

ORIGINAL: obvert

Random testing advocated to help define opening measures after lockdowns.

We are flying blind in the fight against Covid-19. The number of cases is surely much greater than what we see and what is being relied on to provide direction for devising and implementing policy.

But is the true number two to three times higher, as some experts say? More like 10 times, as other analysts calculate? Or perhaps as much as 50 to 100 times higher, as indicated by early random testing in Iceland; a population study of Vò, Italy; and some recent results in California?

The recent Nobel in economic science went to Abhijit Banerjee, Esther Duflo and Michael Kremer, researchers using random control trials, the mainstay of scientific medicine. Their work dramatizes how misleading it can be, for example, to measure disease prevalence by reference to those who seek treatment at rural health clinics, omitting the multitudes who have no access.

Local random tests should be undertaken immediately. University researchers, working with local governments or operating independently, could conduct simple randomization, testing perhaps 5,000 or 10,000 individuals. We would quickly learn whether total cases were five times or 50 times current estimates in those areas.

https://www.nytimes.com/2020/04/24/opin ... Multimedia

Apples and oranges, my man. Apples and oranges.

And, no, I won't spend any more time than the hour I did this morning to elaborate on the issues with Mario Cuomo's 'quick and dirty' serology testing. If you and others blaze on by and don't appreciate my POV here, that's fine with me. But you're off the mark by a long shot.

Come on, folks. Keep it somewhat casual. We would likely all enjoy a beer/shot/whatever together

This is getting a bit odd in Georgia. I'm a bit concerned after two pieces I've just read.

From the Atlanta paper, apparently the Gov's own Coronavirus task force didn't know he was going to announce a reopening until they heard it during the press conference or after. Now one, the daughter of MLK, is threatening to quit.

Key members of the coronavirus task force Gov. Brian Kemp tapped to shape the state’s pandemic strategy said they didn’t know about his decision to reopen some shuttered businesses until he announced it at a press conference.

In interviews and public statements, a half-dozen members of the task force said they only learned about Kemp’s move to let barber shops, theaters and dine-in restaurants begin to resume operations after he made it public. Among them are the leaders of special committees assigned to help inform the public about the state’s efforts to stem the outbreak.

Bernice King, a co-chair of the community outreach committee, said in a video she was considering stepping down after she found out about Kemp’s plans from a text message from a friend. “Like many of you who are in the state of Georgia, I’m extremely concerned about the governor’s plans and what his decisions will mean for the safety, health and lives of Georgia residents,” said King, the chief executive of The King Center and daughter of the slain civil rights leader.

Luckily, many mayors, including the mayor of Atlanta, (who also wasn't told beforehand), are planning to advocate continued measures to keep residents safe.

https://www.ajc.com/blog/politics/membe ... 8pn3gMfLJ/

---

This on the heals of an extensive examination of the situation in Georgia by two data visualisation specialists highlights the potential problems of a reopening now, before the projected peak.

https://www.nytimes.com/interactive/202 ... e=Homepage

An analysis of Georgia’s infection rates, testing and underlying health risks shows why it’s singularly unwise for the state to reopen. Doing so risks a spike in infections just as the virus could be peaking.

Georgia has one of the lowest testing rates in the nation
Less than 1 percent of Georgians have been tested, compared to almost 4 percent of residents in New York and Louisiana.

----------

White House guidelines recommend that state officials wait for a “downward trajectory” over 14 days in either the number of new cases or the share of all tests for the virus that come back positive before they lift business restrictions.

Georgia fails the first test. The number of new cases that its health department has announced each day has trended up over the past two weeks.

----------

“Our state is fragmented by access to health care,” said Dr. Mohammed K. Ali, a professor of epidemiology at Emory University in Atlanta. “The rollback could lead to some pockets with extremely low infection rates and others where the virus spreads like wildfire.”

The Georgia Department of Public Health lists diabetes and heart and lung disease as potential risk factors for severe Covid-19.

Georgia looks like a giant hotspot on maps of all three of those conditions, with communities in the southern part of the state showing especially high incidence rates. The state ranks 19th in share of adults with lung disease and 15th in heart disease.

ORIGINAL: Chickenboy

ORIGINAL: obvert

Random testing advocated to help define opening measures after lockdowns.

We are flying blind in the fight against Covid-19. The number of cases is surely much greater than what we see and what is being relied on to provide direction for devising and implementing policy.

But is the true number two to three times higher, as some experts say? More like 10 times, as other analysts calculate? Or perhaps as much as 50 to 100 times higher, as indicated by early random testing in Iceland; a population study of Vò, Italy; and some recent results in California?

The recent Nobel in economic science went to Abhijit Banerjee, Esther Duflo and Michael Kremer, researchers using random control trials, the mainstay of scientific medicine. Their work dramatizes how misleading it can be, for example, to measure disease prevalence by reference to those who seek treatment at rural health clinics, omitting the multitudes who have no access.

Local random tests should be undertaken immediately. University researchers, working with local governments or operating independently, could conduct simple randomization, testing perhaps 5,000 or 10,000 individuals. We would quickly learn whether total cases were five times or 50 times current estimates in those areas.

https://www.nytimes.com/2020/04/24/opin ... Multimedia

Apples and oranges, my man. Apples and oranges.

And, no, I won't spend any more time than the hour I did this morning to elaborate on the issues with Mario Cuomo's 'quick and dirty' serology testing. If you and others blaze on by and don't appreciate my POV here, that's fine with me. But you're off the mark by a long shot.

I'm not on or off the mark. I'm not an expert. I'm just looking for hope among experts who are working on this right now.

Your POV is fine, and very useful, but it's not the only one and I'm surprised you think this is a counter to your posts. It's just posting what out there.

We will have to know how many people have had it at some point.

ORIGINAL: RangerJoe

That US Navy Captain should not be reinstated. Because of his letter, it became known that the USS Rooseveldt could not be deployed. The Chinese government is now conducting naval operations with no US carrier battle group able to respond. It also pins the USS Roosevelt to a specific place. How is that for operational security? Loose lips sink ships.

If the Chinese Intelligence services are even moderately competent, they would already know that the Roosevelt is not battle ready. The problem with carriers in the modern age is that they are big and unstealthy. We are not anymore in WWII: you cannot hide the fact that she is "strangely" moored in Guam and inoperational during unfriendly manoeuvres in her area (not to talk about how the island is full of sick sailors).

Formally you are right, and I would agree. Given the nature of the emergency, however, the negative impact of her captain's letter is almost null in terms of giving info to a potential enemy while doing a lot of good to American sailors' lives (and the preservation of their training).

Now, with a nuclear powered submarine it would be a wholly different matter.

ORIGINAL: obvert

ORIGINAL: Chickenboy

ORIGINAL: obvert

Random testing advocated to help define opening measures after lockdowns.

We are flying blind in the fight against Covid-19. The number of cases is surely much greater than what we see and what is being relied on to provide direction for devising and implementing policy.

But is the true number two to three times higher, as some experts say? More like 10 times, as other analysts calculate? Or perhaps as much as 50 to 100 times higher, as indicated by early random testing in Iceland; a population study of Vò, Italy; and some recent results in California?

The recent Nobel in economic science went to Abhijit Banerjee, Esther Duflo and Michael Kremer, researchers using random control trials, the mainstay of scientific medicine. Their work dramatizes how misleading it can be, for example, to measure disease prevalence by reference to those who seek treatment at rural health clinics, omitting the multitudes who have no access.

Local random tests should be undertaken immediately. University researchers, working with local governments or operating independently, could conduct simple randomization, testing perhaps 5,000 or 10,000 individuals. We would quickly learn whether total cases were five times or 50 times current estimates in those areas.

https://www.nytimes.com/2020/04/24/opin ... Multimedia

Apples and oranges, my man. Apples and oranges.

And, no, I won't spend any more time than the hour I did this morning to elaborate on the issues with Mario Cuomo's 'quick and dirty' serology testing. If you and others blaze on by and don't appreciate my POV here, that's fine with me. But you're off the mark by a long shot.

I'm not on or off the mark. I'm not an expert. I'm just looking for hope among experts who are working on this right now.

Your POV is fine, and very useful, but it's not the only one and I'm surprised you think this is a counter to your posts. It's just posting what out there.

We will have to know how many people have had it at some point.

Agreed. You're not an expert. Disagreed. You are off the mark still. No the reference isn't a counter to my posts. By omission, not acknowledging the effort of meaningful replies is. There are plenty of 'what's out there' to go around. Weigh random indecipherable internet garbage through whatever lens you see fit. But I won't waste my time trying to point you in the right direction any further.

Thought this was interesting timing:


https://www.cnbc.com/2020/04/24/fda-iss ... orted.html

Especially in light of the 'accidental leak' of information about remdesivir from the WHO yesterday:

https://www.fool.com/investing/2020/04/ ... r-fai.aspx

Glad Gilead responded rapidly, objectively and stridently to this 'accidental leak' from WHO.

Anybody else here think there's some Chicom disinformation at play? A promising and effective treatment developed (by an American company) through recognized appropriate Western studies? Better cast some shade. Refutation of HCQ treatment through solid research? But...but...but the Chinese said that works for them and we should all embrace the munificent knowledge of harmony of Chairman Winnie...erm...Jinping.

If it doesn't fit the Chicom ("we're a world player and we really know what we're doing") narrative, it gets smeared.

ORIGINAL: Chickenboy

ORIGINAL: obvert

ORIGINAL: Chickenboy




Apples and oranges, my man. Apples and oranges.

And, no, I won't spend any more time than the hour I did this morning to elaborate on the issues with Mario Cuomo's 'quick and dirty' serology testing. If you and others blaze on by and don't appreciate my POV here, that's fine with me. But you're off the mark by a long shot.

I'm not on or off the mark. I'm not an expert. I'm just looking for hope among experts who are working on this right now.

Your POV is fine, and very useful, but it's not the only one and I'm surprised you think this is a counter to your posts. It's just posting what out there.

We will have to know how many people have had it at some point.

Agreed. You're not an expert. Disagreed. You are off the mark still. No the reference isn't a counter to my posts. By omission, not acknowledging the effort of meaningful replies is. There are plenty of 'what's out there' to go around. Weigh random indecipherable internet garbage through whatever lens you see fit. But I won't waste my time trying to point you in the right direction any further.

Very odd you'd have this response coming from a scientific background. I just realised I think you had assumed I was posting an article about "Cuomo's 'quick and dirty' serology testing," as you put it.

The article I referenced doesn't site that example, but is about other studies of the effectiveness of randomisation as a tool to understand prevalence of X in a population or group and how we need that to send people back to work.

"By omission, not acknowledging the effort of meaningful replies" was a counter to your post? Your post wasn't in response to me or to the article I posted! I'll be sure to acknowledge your effort in future, especially when you're writing to another forum member about his post containing different information to my later post. [:D]

I'm weighing things alright, and I'm beginning to see how relative weight is depending on the viewpoint. [;)]