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RE: FROM THE RED ZONE
Posted: Sat Mar 21, 2020 8:49 pm
by Jace11
ORIGINAL: RangerJoe
ORIGINAL: Jace11
Yup... ACE2 may be the key. It is also crucial in mitigating lung damage. ACE2 knock-out mice become very leaky after lung tissue damage, this is expected, as the angiotensin system is out of balance. Mice challenged with the the old SARS looked like there was no ACE2 in the lungs. ACE2 is an important factor in protecting the lung from damage, but this virus is targeting those pneumocytes that express it (probably exclusively - as this is the target of the S-protein).
It's a double whammy attack! A lung infection that also takes out the lungs ability to mitigate the damage. It's also X-linked, and there is a 2:1 gender bias is severe cases and deaths, but this could also be explained by other factors (men drink, smoke, and are more prone to high BP, cardiovascular dz). Type I and II Diabetes have upregulated ACE2 too (often prescribed ACE blockers and ARBs) - that is another reported comorbidity.
Recombinant soluble ACE2 is close to clinical trials in China.
The hypertension bias in the latest Italian data ... 76%
https://www.epicentro.iss.it/coronaviru ... rzo-v2.pdf
I had already mentioned ACE2 and possibly using free ACE2 to bind with the virus so it will not be able to infect cells. But the ACE channel blockers are a different ACE.
Yup, that's right they have different activities (I think 40% homology though - both are membrane-bound carboxypeptidases acting on the same peptide), but ACE blockers have been shown to alter ACE2 expression levels in both animals and humans in various tissues.
Here is a short balanced article looking at the dangers of upregulation of ACE2 by ACE blockers and ARBs vs the possible benefits of ARBs as therapeutics, soluble ACE2 gets mentioned again.
https://academic.oup.com/eurheartj/adva ... 35/5810479
RE: FROM THE RED ZONE
Posted: Sat Mar 21, 2020 10:18 pm
by balto
WoW! I normally do not come to Matrix as often as I have been unless it is something new that is coming which I am interested in which is Shadow Empires (which is going to awesome) and Pz Corp 2 (pretty good). I always assumed that most of us were not the doom-and-gloom types because I also assumed there was some higher intelligence mixed-in with the types of games we play/love. I was wrong, even the ones with math skills. I see again another TOAW person (should rename that group the "Sky Is Falling Little Boys") saying something about Maryland and the National Guard and the pic of their Humvees and Martial law.., sounds ominous and spooky especially with the pics of them "hiding" under the underpass. The reason they are under the overpass is because that is the parking lot of our stadium which has lots of parking and is wide open and logistically it would take a local commander about 1.5 minutes to realize this is the marshalling area. I have lived just outside of the city and worked in it my whole life - we are 100% fine and the NG is distributing food and helping other Americans get what they need within the city - food distribution, etc.., Thank goodness for the National Guard..,
PS - Italy and Spain, sorry that you are going through so much. If you are scared, hide it so that those around you feed off of that confidence, even if it is false-confidence - this is what is called being a man. Stay strong and help your neighbor if you can, you will get through this.
RE: FROM THE RED ZONE
Posted: Sat Mar 21, 2020 10:23 pm
by RangerJoe
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 12:49 am
by rico21
ORIGINAL: balto
WoW! I normally do not come to Matrix as often as I have been unless it is something new that is coming which I am interested in which is Shadow Empires (which is going to awesome) and Pz Corp 2 (pretty good). I always assumed that most of us were not the doom-and-gloom types because I also assumed there was some higher intelligence mixed-in with the types of games we play/love. I was wrong, even the ones with math skills. I see again another TOAW person (should rename that group the "Sky Is Falling Little Boys") saying something about Maryland and the National Guard and the pic of their Humvees and Martial law.., sounds ominous and spooky especially with the pics of them "hiding" under the underpass. The reason they are under the overpass is because that is the parking lot of our stadium which has lots of parking and is wide open and logistically it would take a local commander about 1.5 minutes to realize this is the marshalling area. I have lived just outside of the city and worked in it my whole life - we are 100% fine and the NG is distributing food and helping other Americans get what they need within the city - food distribution, etc.., Thank goodness for the National Guard..,
PS - Italy and Spain, sorry that you are going through so much. If you are scared, hide it so that those around you feed off of that confidence, even if it is false-confidence - this is what is called being a man. Stay strong and help your neighbor if you can, you will get through this.
Is lying to others, pretending to be a man?
Rather tell the truth and assume!
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 6:55 am
by Zorch
'COVID-19 coronavirus epidemic has a natural origin'
https://www.sciencedaily.com/releases/2 ... 175442.htm
'An analysis of public genome sequence data from SARS-CoV-2 and related viruses found no evidence that the virus was made in a laboratory or otherwise engineered.'
'The novel SARS-CoV-2 coronavirus that emerged in the city of Wuhan, China, last year and has since caused a large scale COVID-19 epidemic and spread to more than 70 other countries is the product of natural evolution, according to findings published today in the journal Nature Medicine.'
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 9:07 am
by sPzAbt653
I didn't think there would be such a reaction, otherwise I would have explained further. Question everything, especially when it comes to Maryland, one of the biggest asshole states. When Md. is up to something, it is usually bad news.
Here is the overhead of the area. Maybe not obvious to those not familiar with this place, but there is a lot of parking all around. The MNG is hiding under the overpass where the red X is. If that isn't obvious enough to make you ask why, see the next photo.
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 9:10 am
by sPzAbt653
I 'Street Viewed' to get this spot, at the blue X in the previous photo. This is from a different time of course, but this is where the MNG are currently hiding. It is the one place in the staging area that is almost completely hidden from view.
And yes, they are here for humanitarian reasons, as I said in the original report.
Question everything, better safe than gullible. [:)]
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 10:07 am
by Red2112
They knew what could happen two months before the outbreak. Probably even years before that! There´s NO excuse as to how goverments are dealing with this, and WE as citizens of the world should be aware of that! The goverments are at our service, that´s why we vote for them, and NOT the other way around!
Was Event 201 just a waste of time?
http://www.centerforhealthsecurity.org/event201/about
Was the major doctors opinion a waste of time too?
After the outbreak in China, what more did goverments need to know? If that wasent enough, then Italy came along and there were still speculating, then Spain, and then the rest of EU before they even started to take actions!
Oh but no worries, they are working on a cure in the meantime while others die. But don´t panic, will give you a vaccine of which you wont know what it will really do to you and the new born till the next generation comes, and again, meantime they will make a profit off of it. Will also give you money of which we will get back in the years to come by rising your taxes, and rescueing (with our money) those companies who were already in a pitfall before all this happened.
And your still worried about some statistic numbers that nobody really knows if they are true, or comments on media that are owned by those who only care about there money? Ever heard of social engineering? This is just the first wave of similar incidents to come, it all depends on how we react.
Nobody has knocked on my door ever asking what I think should be done, about ANYTHING, but then Iam asked to trust those above that do as they please.
Really? Get in check with yourself...
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 10:49 am
by MrRoadrunner
1984 coming in 2020?
RR
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 11:35 am
by Lobster
ORIGINAL: Red2112
They knew what could happen two months before the outbreak. Probably even years before that! There´s NO excuse as to how goverments are dealing with this, and WE as citizens of the world should be aware of that! The goverments are at our service, that´s why we vote for them, and NOT the other way around!
Was Event 201 just a waste of time?
http://www.centerforhealthsecurity.org/event201/about
Was the major doctors opinion a waste of time too?
After the outbreak in China, what more did goverments need to know? If that wasent enough, then Italy came along and there were still speculating, then Spain, and then the rest of EU before they even started to take actions!
Oh but no worries, they are working on a cure in the meantime while others die. But don´t panic, will give you a vaccine of which you wont know what it will really do to you and the new born till the next generation comes, and again, meantime they will make a profit off of it. Will also give you money of which we will get back in the years to come by rising your taxes, and rescueing (with our money) those companies who were already in a pitfall before all this happened.
And your still worried about some statistic numbers that nobody really knows if they are true, or comments on media that are owned by those who only care about there money? Ever heard of social engineering? This is just the first wave of similar incidents to come, it all depends on how we react.
Nobody has knocked on my door ever asking what I think should be done, about ANYTHING, but then Iam asked to trust those above that do as they please.
Really? Get in check with yourself...
Well we could all go back and look at how the majority of people said everyone was over reacting and it was much ado about nothing. [:D]
https://www.youtube.com/watch?v=6pKRP1DmRAU
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 11:51 am
by MrsWargamer
I'm at serious risk of finishing all my models if something doesn't change soon
This week it has been an M3 Grant, Pz IIIl, Tiger mid prod, King Tiger (P) turret, flakpz IV mobelwagen, quad gun tractor, and currently working on a birdcage Corsair and an FW 190 F8/9 as well as a 747 and an AN 225 (it's bloody big).
I might even get around to playing a wargame !!
Currently blaring Armin van Buuren from YouTube to feel like I'm actually at a social event I'm not really convinced.
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 11:54 am
by Curtis Lemay
I'm switching to graphical. Today's worldwide figures (Wikipedia):
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 11:58 am
by Zorch
ORIGINAL: MrsWargamer
I'm at serious risk of finishing all my models if something doesn't change soon
This week it has been an M3 Grant, Pz IIIl, Tiger mid prod, King Tiger (P) turret, flakpz IV mobelwagen, quad gun tractor, and currently working on a birdcage Corsair and an FW 190 F8/9 as well as a 747 and an AN 225 (it's bloody big).
I might even get around to playing a wargame !!
Currently blaring Armin van Buuren from YouTube to feel like I'm actually at a social event I'm not really convinced.
Try the History Guy on YouTube - he'll keep you busy for days. [;)]
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 12:00 pm
by RangerJoe
ORIGINAL: MrsWargamer
I'm at serious risk of finishing all my models if something doesn't change soon
This week it has been an M3 Grant, Pz IIIl, Tiger mid prod, King Tiger (P) turret, flakpz IV mobelwagen, quad gun tractor, and currently working on a birdcage Corsair and an FW 190 F8/9 as well as a 747 and an AN 225 (it's bloody big).
I might even get around to playing a wargame !!
Currently blaring Armin van Buuren from YouTube to feel like I'm actually at a social event I'm not really convinced.
If they are all the same scale, are you going to build a diorama? If so, please post a picture of it.
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 12:03 pm
by RangerJoe
ORIGINAL: Curtis Lemay
I'm switching to graphical. Today's worldwide figures (Wikipedia):
Did you know that posting misleading information artificially showing things are worse leads to panic? The panic can be worse than the threat? This can lead to hoarding and price gouging? That is one reason why people do present misleading information.
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 12:25 pm
by MrsWargamer
ORIGINAL: RangerJoe
ORIGINAL: MrsWargamer
I'm at serious risk of finishing all my models if something doesn't change soon
This week it has been an M3 Grant, Pz IIIl, Tiger mid prod, King Tiger (P) turret, flakpz IV mobelwagen, quad gun tractor, and currently working on a birdcage Corsair and an FW 190 F8/9 as well as a 747 and an AN 225 (it's bloody big).
I might even get around to playing a wargame !!
Currently blaring Armin van Buuren from YouTube to feel like I'm actually at a social event I'm not really convinced.
If they are all the same scale, are you going to build a diorama? If so, please post a picture of it.
I don't routinely do dioramas (kills too much shelf). Most of my collection sits on shelves like it was a parking lot
I'll see if I can generate some pictures.
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 12:41 pm
by Lobster
ORIGINAL: RangerJoe
Did you know that posting misleading information artificially showing things are worse leads to panic? The panic can be worse than the threat? This can lead to hoarding and price gouging? That is one reason why people do present misleading information.
Opinions are like belly buttons. Everyone has one. [:D]
https://www.businessinsider.com/coronav ... ses-2020-3
https://www.cebm.net/global-covid-19-ca ... ity-rates/
https://www.worldometers.info/coronavirus/
And those are just the ones I bothered to look at. I've seen numbers that are all over the place from 1% to 12% for total fatalities when all is said and that from the people who do the science, not people telling everyone their opinion is the right one and anyone else is stupid. You will never know until it's over. If you think otherwise you are delusional.
If you are concerned about yourself or family numbers ignore global numbers and just worry about local. The global numbers are of no help to you.
The state I live in has 23 cases and no deaths. Mostly concentrated in a large metro area.
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 12:49 pm
by loki100
ORIGINAL: Curtis Lemay
I'm switching to graphical. Today's worldwide figures (Wikipedia):
..
I'm impressed, you can divide figures that have no relation to each other ... and show the results in a graph
chapeaux
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 12:51 pm
by Lobster
ORIGINAL: loki100
ORIGINAL: Curtis Lemay
I'm switching to graphical. Today's worldwide figures (Wikipedia):
..
I'm impressed, you can divide figures that have no relation to each other ... and show the results in a graph
chapeaux
I'm impressed too. Some people can spout the same tripe over and over like a school yard bully. Why do you people attack someone over and over again about the exact same thing? You made your point. It's shameful.
RE: FROM THE RED ZONE
Posted: Sun Mar 22, 2020 2:13 pm
by Toby42
ORIGINAL: Curtis Lemay
I'm switching to graphical. Today's worldwide figures (Wikipedia):
I must be missing something. Using the posted figures the death rate is 4.2% (13071/308615 = 0.042 ?