Moderators: wdolson, MOD_War-in-the-Pacific-Admirals-Edition
ORIGINAL: obvert
This looks very interesting. A very clear breakdown of how immunity works, how vaccines can be developed to take advantage of weak points in a virus, and how we shouldn't worry that we won't have immunity if we've recently had this particular disease.
https://www.nytimes.com/2020/07/31/opin ... e=Homepage
That antibodies decrease once an infection recedes isn’t a sign that they are failing: It’s a normal step in the usual course of an immune response.
Nor does a waning antibody count mean waning immunity: The memory B cells that first produced those antibodies are still around, and standing ready to churn out new batches of antibodies on demand.
; Julia Child
ORIGINAL: sPzAbt653
The damn virus has a bad habit of mutating frequently. I haven't seen any research on whether antibodies are still effective on all the variants. Since it would be unethical to give someone all the virus variants, we would have to do a huge amount of research on large pools of people who have had the virus. That won't likely happen soon - too many more urgent things for scientists to look at right now. Not trying to be a killjoy on our hopes, but we need to temper our expectations and not assume that those who have had it can go about with no precautions.ORIGINAL: RangerJoe
ORIGINAL: obvert
This looks very interesting. A very clear breakdown of how immunity works, how vaccines can be developed to take advantage of weak points in a virus, and how we shouldn't worry that we won't have immunity if we've recently had this particular disease.
https://www.nytimes.com/2020/07/31/opin ... e=Homepage
That antibodies decrease once an infection recedes isn’t a sign that they are failing: It’s a normal step in the usual course of an immune response.
Nor does a waning antibody count mean waning immunity: The memory B cells that first produced those antibodies are still around, and standing ready to churn out new batches of antibodies on demand.
I had reported on the B cells earlier but this adds new information. Thank you.
Long Island checking in......Sharks, way more sharks than a normal year. Ocean beaches closed to swimming multiple times a day. Bull sharks so far, which are nasty. Great Whites usually are here in numbers in August.ORIGINAL: Sardaukar
I'd not mind some Aliens...would be welcome break from Covid, locusts, murder hornets etc.....[:D][8D]
ORIGINAL: JohnDillworth
Long Island checking in......Sharks, way more sharks than a normal year. Ocean beaches closed to swimming multiple times a day. Bull sharks so far, which are nasty. Great Whites usually are here in numbers in August.
ORIGINAL: BBfanboy
The damn virus has a bad habit of mutating frequently. I haven't seen any research on whether antibodies are still effective on all the variants. Since it would be unethical to give someone all the virus variants, we would have to do a huge amount of research on large pools of people who have had the virus. That won't likely happen soon - too many more urgent things for scientists to look at right now. Not trying to be a killjoy on our hopes, but we need to temper our expectations and not assume that those who have had it can go about with no precautions.ORIGINAL: RangerJoe
ORIGINAL: obvert
This looks very interesting. A very clear breakdown of how immunity works, how vaccines can be developed to take advantage of weak points in a virus, and how we shouldn't worry that we won't have immunity if we've recently had this particular disease.
https://www.nytimes.com/2020/07/31/opin ... e=Homepage
That antibodies decrease once an infection recedes isn’t a sign that they are failing: It’s a normal step in the usual course of an immune response.
Nor does a waning antibody count mean waning immunity: The memory B cells that first produced those antibodies are still around, and standing ready to churn out new batches of antibodies on demand.
I had reported on the B cells earlier but this adds new information. Thank you.
You are talking vaccines, I was talking antibodies, which might target a different part of the virus. There are at least seven different versions of the virus.ORIGINAL: obvert
ORIGINAL: BBfanboy
The damn virus has a bad habit of mutating frequently. I haven't seen any research on whether antibodies are still effective on all the variants. Since it would be unethical to give someone all the virus variants, we would have to do a huge amount of research on large pools of people who have had the virus. That won't likely happen soon - too many more urgent things for scientists to look at right now. Not trying to be a killjoy on our hopes, but we need to temper our expectations and not assume that those who have had it can go about with no precautions.ORIGINAL: RangerJoe
I had reported on the B cells earlier but this adds new information. Thank you.
It is actually showing to mutate much less quickly than other viruses. In the article it mentions how it's not HIV, which does have such quick mutations it's impossible to create a vaccine.
The variants that exist now don't differ enough in ways that would inhibit current vaccines in trials from working. In fact vaccines are being made for virtually all areas and methods of fighting the virus, and there are many parts that can be used. Only very minor mutations are happening with Coronavirus and in areas that would not change either natural or vaccine immunity as scientists now see it, from what I've read.
There was a report yesterday of a woman in the Lake of the Woods area getting her leg ripped by a muskellunge big enough to pull her under. Nearby people had to grab her to keep the fish from swimming off with her. That has to be a record muskie!ORIGINAL: JohnDillworth
Long Island checking in......Sharks, way more sharks than a normal year. Ocean beaches closed to swimming multiple times a day. Bull sharks so far, which are nasty. Great Whites usually are here in numbers in August.ORIGINAL: Sardaukar
I'd not mind some Aliens...would be welcome break from Covid, locusts, murder hornets etc.....[:D][8D]
ORIGINAL: BBfanboy
There was a report yesterday of a woman in the Lake of the Woods area getting her leg ripped by a muskellunge big enough to pull her under. Nearby people had to grab her to keep the fish from swimming off with her. That has to be a record muskie!ORIGINAL: JohnDillworth
Long Island checking in......Sharks, way more sharks than a normal year. Ocean beaches closed to swimming multiple times a day. Bull sharks so far, which are nasty. Great Whites usually are here in numbers in August.ORIGINAL: Sardaukar
I'd not mind some Aliens...would be welcome break from Covid, locusts, murder hornets etc.....[:D][8D]
; Julia ChildSEOUL (Reuters) - Samsung Electronics Co will halt operations of its last computer factory in China, the South Korean tech giant said on Saturday, the latest manufacturer to shift production from the world’s second-biggest economy.
Companies are rethinking their production and supply chains amid . . . the blow from the COVID-19 pandemic.
; Julia ChildORIGINAL: BBfanboy
You are talking vaccines, I was talking antibodies, which might target a different part of the virus. There are at least seven different versions of the virus.ORIGINAL: obvert
ORIGINAL: BBfanboy
The damn virus has a bad habit of mutating frequently. I haven't seen any research on whether antibodies are still effective on all the variants. Since it would be unethical to give someone all the virus variants, we would have to do a huge amount of research on large pools of people who have had the virus. That won't likely happen soon - too many more urgent things for scientists to look at right now. Not trying to be a killjoy on our hopes, but we need to temper our expectations and not assume that those who have had it can go about with no precautions.
It is actually showing to mutate much less quickly than other viruses. In the article it mentions how it's not HIV, which does have such quick mutations it's impossible to create a vaccine.
The variants that exist now don't differ enough in ways that would inhibit current vaccines in trials from working. In fact vaccines are being made for virtually all areas and methods of fighting the virus, and there are many parts that can be used. Only very minor mutations are happening with Coronavirus and in areas that would not change either natural or vaccine immunity as scientists now see it, from what I've read.
I suspect this has more to do with the authoritarian moves of the CCP on Hong Kong and the ethinic group they are sending to 're-education camps' and forcing sterilization of their women. Perhaps also China not putting pressure on N. Korea to cease its sabre rattling at S. Korea.ORIGINAL: RangerJoe
Samsung Electronics to halt production at its last computer factory in China
SEOUL (Reuters) - Samsung Electronics Co will halt operations of its last computer factory in China, the South Korean tech giant said on Saturday, the latest manufacturer to shift production from the world’s second-biggest economy.
Companies are rethinking their production and supply chains amid . . . the blow from the COVID-19 pandemic.
https://www.reuters.com/article/us-sams ... SKBN24X3K4
It did not state where the production was moving to.
There was a report last month that researchers in SPAIN had found genetic evidence of the virus in a case from early 2019. Just one more mystery about this thing.ORIGINAL: obvert
Actually I am talking both. There are different versions, but read about them. It's changed remarkably little between variants, and the dominant form now appears to simply be just enough more contagious (with a variation on the spike protein connector) to have begun to dominate all other variants.
Being more contagious makes it more dangerous, but also would actually make it easier to get immunity to currently since this variant is beginning to dominate the worldwide outbreak.
https://www.sciencedaily.com/releases/2 ... 144054.htm
The SARS-CoV-2 virus has a low mutation rate overall (much lower than the viruses that cause influenza and HIV-AIDS). The D614G variant appears as part of a set of four linked mutations that appear to have arisen once and then moved together around the world as a consistent set of variations.
"It's remarkable to me," commented Will Fischer of Los Alamos, an author on the study, "both that this increase in infectivity was detected by careful observation of sequence data alone, and that our experimental colleagues could confirm it with live virus in such a short time."
Fortunately, "the clinical data in this paper from Sheffield showed that even though patients with the new G virus carried more copies of the virus than patients infected with D, there wasn't a corresponding increase in the severity of illness," said Saphire, who leads the Gates Foundation-supported Coronavirus Immunotherapy Consortium (CoVIC).
This is interesting.
The attention lavished on G614 may obscure a bigger question, however: With the virus having spread to at least 11 million people worldwide, why aren’t more mutations that affect its behavior emerging?
Perhaps there’s just little selection pressure on the virus as it races through millions of immunologically naïve people, scientists say. That could change with the advent of vaccines or new therapies, forcing the virus to evolve. But it could also indicate that the virus has been with people longer than we know, and was spreading before the first known cases in Wuhan, China, in December 2019. “The evolution of this virus to become a human pathogen may have already happened and we missed it,” Rasmussen says.
Wang thinks a version of the virus may have circulated earlier in humans in southern Asia, perhaps flying under the radar because it didn’t cause severe disease. “If it happens in a small or remote village, even with some people dying, nobody is going to know there’s a spillover,” Wang says. The virus could then have infected an animal that was brought to Wuhan and started the pandemic.
At Dutch mink farms, after all, the virus jumped not just from humans to animals, but also back from animals to humans, Wang says. “If that can happen in the Netherlands, surely it can happen in a village in Thailand, or in Yunnan province in southern China.”
https://www.sciencemag.org/news/2020/07 ... -dangerous
My cloth mask - made by a lady in Winnipeg - has pouch between layers in which you can insert a shop-towel filter (a kind of lint-free cloth). The instructions are to soak the liner in heavily salted water and then dry it before placing it in the mask pouch. The salt absorbs moisture and can kill germs. Every so often you can take it out and renew the salt.ORIGINAL: obvert
This also interesting. Sill looking at the Diamond princess as an enclosed case study in transmission. Aerosols becoming more and more likely as main mode of transmission.
https://www.nytimes.com/2020/07/30/heal ... e=Homepage
In a new report, a research team based at Harvard and the Illinois Institute of Technology has tried to tease out the ways in which the virus passed from person to person in the staterooms, corridors and common areas of the Diamond Princess. It found that the virus spread most readily in microscopic droplets that were light enough to float in the air, for several minutes or much longer.
For example, ventilation systems that “turn over” or replace the air in a room or building as often as possible, preferably drawing on external air to do so, should make indoor spaces healthier. But good ventilation is not enough; the Diamond Princess was well ventilated and the air did not recirculate, the researchers noted. So wearing good-quality masks — standard surgical masks, or cloth masks with multiple layers rather than just one — will most likely be needed as well, even in well-ventilated spaces where people are keeping their distance.
; Julia ChildI hope you are over the illness you felt a while back?ORIGINAL: RangerJoe
I reported earlier about a mask with replaceable N-95 filters, the mask itself is washable.
But people have to learn that when you are ill that you take precautions so they do not share what they have.[:@]
