OT: Corona virus

[MakeeLearn]

A Heart Attack? No, It Was the Coronavirus
March 27, 2020

https://www.nytimes.com/2020/03/27/heal ... tacks.html



"The Brooklyn patient had myocarditis, an inflammation of the heart that has been seen in patients with other viral infections, such as MERS — also caused by a coronavirus — and the H1N1 swine flu.

But the new coronavirus, called SARS-CoV-2, mostly infects the lungs, causing pneumonia in severe cases. Believing it caused respiratory disease, many cardiologists thought the coronavirus was outside their specialty."

[MakeeLearn]

"It is possible — but not yet established — that myocarditis results from an immune system that lurches out of control while trying to turn back the coronavirus, pumping out such excessive levels of chemicals called cytokines that cause inflammation that they damage the lungs and the heart alike."

[MakeeLearn]

Coronavirus Might Attack the Brain, Too
Apr 9 2020

https://elemental.medium.com/coronaviru ... ea92a39c04


"The cells with the right receptors for SARS-CoV-2 are found extensively in the lungs, Rao tells Elemental, explaining why breathing problems are common in severe Covid-19 cases. But those receptors are also found in blood vessels in the blood-brain barrier and in nerve endings, he explains.

“It is definitely possible that the nervous system is being invaded through these means,” Rao says."


---------------

It's getting thru the BBB, Blood-Brain Barrier

[MakeeLearn]

HIDDEN KILLER Fears coronavirus can HIDE in cells and reactivate later after 51 recovered patients test positive again

6 Apr 2020

https://www.thesun.co.uk/news/11340989/ ... -positive/

"The center said it did not believe the patients had been reinfected, but that the virus had remained at undetectable levels in their cells and later "reactivated".

The claim runs contrary to the bulk of current evidence about how the virus works.

Speaking to MailOnline, Paul Hunter, an infectious diseases professor at the University of East Anglia, said: "I agree that these will not be reinfections but I do not think these will be reactivations."


----------------
hmmmmmmmmmm...

Hangs around inside of a cell in a disassembled state, then re-begins viral assembly under certain conditions.?

[BBfanboy]

ORIGINAL: MakeeLearn

Coronavirus Might Attack the Brain, Too
Apr 9 2020

https://elemental.medium.com/coronaviru ... ea92a39c04


"The cells with the right receptors for SARS-CoV-2 are found extensively in the lungs, Rao tells Elemental, explaining why breathing problems are common in severe Covid-19 cases. But those receptors are also found in blood vessels in the blood-brain barrier and in nerve endings, he explains.

“It is definitely possible that the nervous system is being invaded through these means,” Rao says."


---------------

It's getting thru the BBB, Blood-Brain Barrier

Does not having a brain make me immune to that?

[BBfanboy]

ORIGINAL: MakeeLearn

HIDDEN KILLER Fears coronavirus can HIDE in cells and reactivate later after 51 recovered patients test positive again

6 Apr 2020

https://www.thesun.co.uk/news/11340989/ ... -positive/

"The center said it did not believe the patients had been reinfected, but that the virus had remained at undetectable levels in their cells and later "reactivated".

The claim runs contrary to the bulk of current evidence about how the virus works.

Speaking to MailOnline, Paul Hunter, an infectious diseases professor at the University of East Anglia, said: "I agree that these will not be reinfections but I do not think these will be reactivations."


----------------
hmmmmmmmmmm...

Hangs around inside of a cell in a disassembled state, then re-begins viral assembly under certain conditions.?

Other experts say that likely their first test was a false positive, and the later test was the first time they had the virus.

[MakeeLearn]

ORIGINAL: BBfanboy

ORIGINAL: MakeeLearn

Coronavirus Might Attack the Brain, Too
Apr 9 2020

https://elemental.medium.com/coronaviru ... ea92a39c04


"The cells with the right receptors for SARS-CoV-2 are found extensively in the lungs, Rao tells Elemental, explaining why breathing problems are common in severe Covid-19 cases. But those receptors are also found in blood vessels in the blood-brain barrier and in nerve endings, he explains.

“It is definitely possible that the nervous system is being invaded through these means,” Rao says."


---------------

It's getting thru the BBB, Blood-Brain Barrier

Does not having a brain make me immune to that?

Hmmmmmmmmm...

[BBfanboy]

Here's something really disturbing: Brazil's problem-denial government and zeal for economic development above all else has brought Covid-19 to remote regions of the Amazon already. [:(]

https://www.cnn.com/2020/04/10/world/ya ... index.html

[MakeeLearn]

The Bats Behind the Pandemic
From Ebola to Covid-19, many of the deadliest viruses to emerge in recent years have the same animal source.

April 9, 2020

https://www.wsj.com/articles/the-bats-b ... 1586440959

Behind a wall.....


By Matt Ridley, Wall Street Journal, April 9, 2020:

RaTG13 is the name, rank and serial number of an individual horseshoe bat of the species Rhinolophus affinis, or rather of a sample of its feces collected in 2013 in a cave in Yunnan, China. The sample was collected by hazmat-clad scientists from the Institute of Virology in Wuhan that year. Stored away and forgotten until January this year, the sample from the horseshoe bat contains the virus that causes Covid-19.

The scientists were mostly sampling a very similar species with slightly shorter wings, called Rhinolophus sinicus, in a successful search for the origin of the virus responsible for the SARS epidemic of 2002-03. That search had alarming implications, which were largely ignored.

In Shi tou Cave, south of Kunming, the capital of Yunnan, they found viruses in the bats droppings and anal swabs that were more similar to human SARS than anything found in palm civets, the small mammals that until then were presumed to be the source of human infection. Back in the laboratory, they found that one of the viruses from bat droppings, called WIV1, could thrive in monkey and human cells specially engineered to activate the gene for ACE2 receptors, the lock to which a coronavirusâs spike protein can fit as a key. This suggested that people could catch SARS directly from a bat dropping.

Then in 2016, Ralph Baric and colleagues at the University of North Carolina at Chapel Hill showed that the same bat virus could infect live mice that had been engineered to express the human gene for the ACE2 receptor. The virus was poised for human emergence, as the title of Dr. Baricâ's paper put it.

[….]

Significantly, the same analysis shows that the most recent common ancestor of the human virus and the RaTG13 virus lived at least 40 years ago. So it is unlikely that the cave in Yunnan (a thousand miles from Wuhan) is where the first infection happened or that the culprit bat was taken from that cave to Wuhan to be eaten or experimented on.

Rather, it is probable that somewhere much closer to Wuhan, there is another colony of bats carrying the same kind of virus. Unless other evidence emerges, it thus looks like a horrible coincidence that China's Institute of Virology, a high-security laboratory where human cells were being experimentally infected with bat viruses, happens to be in Wuhan, the origin of todays pandemic.

[MakeeLearn]

Philippines backs Vietnam after China sinks fishing boat
Apr 8, 2020


https://globegazette.com/news/world/phi ... 5e1cd.html


"he Philippines on Wednesday expressed solidarity with Vietnam after Hanoi protested what it said was the ramming and sinking of a Vietnamese fishing boat by a Chinese coast guard ship in the disputed South China Sea.

The Department of Foreign Affairs in Manila expressed deep concern over the reported April 3 sinking of the boat carrying eight fishermen off the Paracel Islands. The incident happened at a time when common approach was crucial in confronting the coronavirus pandemic, it said.

“COVID-19 is a very real threat that demands unity and mutual trust,” the department said. “In the face of it, neither fish nor fictional historical claims are worth the fuse that’s lit by such incidents.”"

[JohnDillworth]

"The Brooklyn patient had myocarditis, an inflammation of the heart that has been seen in patients with other viral infections, such as MERS — also caused by a coronavirus — and the H1N1 swine flu.

But the new coronavirus, called SARS-CoV-2, mostly infects the lungs, causing pneumonia in severe cases. Believing it caused respiratory disease, many cardiologists thought the coronavirus was outside their specialty."

real uptick of Heart Attacks in NYC.....................................https://www.nbcnews.com/health/health-news/cardiac-calls-911-new-york-city-surge-they-may-really-n1179286

[Cap Mandrake]

ORIGINAL: Canoerebel

Cap, I've heard secondhand stories of serious complications, etc. like lung issues. Those weren't reliable sources and didn't mention whether the issues were temporary or permanent.

Do you have a shorthand synopsis of side effects (preferably in reasonable layman lingo)?

Thanks.

Possible lung problems in recovered (or acutely ill) COVID patients:

1) Barotrauma (literally injury to the lung from positive pressure ventilation). A serious risk when the ventilatory support is prolonged or extreme. this may be permanent.

2) Lung scarring from the viral pneumonia and inflammatory processes itself. This may be permanent or take a long time to go away.

3) Pulmonary hypertension...elevation of pressure in the pulmonary arteries. Bad. Can cause "right to left shunting and severe depression or arterial oxygen levels. There is a trial in the US of Nitric Oxide gas during ventilation to reduce this.

4) Pulmonary embolism. Blood clots propagating in the extremity veins or even the heart and moving downstream to the lungs. Very, very bad.

[Ian R]

Today's figures from Oz - numbers gradually falling.

As at 6:00am on 11 April 2020, there have been 6,238 confirmed cases of COVID-19 in Australia. There have been 86 new cases since 6:00am yesterday.

The graph looks like this:

[Cap Mandrake]

One bit of good news.

SARS targeted the human ACE2 protein for cell attachment. This raised the question of the super-valuable medications for hypertension, ACE-inhibitors and ARB's were DANGEROUS in COVID (because the tended to INCREASE ACE-2)

It turns out COVID targets a COMPLETELY different cell surface protein than SARS so that concern seems invalid...the bad news?

The new human cell membrane protein targeted by COVID is prevalent in the UPPER respiratory tract. This accounts perhaps for the massively increased contagiousness of COVID compared to SARS.

How did this happen? There is likely some cell membrane protein in Horseshoe Bats with remarkable conserved properties compared to the equivalent properties in the human equivalent cell membrane protein and the f****** mutated COVID spike protein sticks to it like a m***** f******* lock and key and bat woman in the Wuhan lab managed to find the thing crawling around in the guano....or the wet market theory is correct.

The damndest thing is it took thousands or millions of mutations to "luck" upon this lock and key.

[Ian R]

According to worldometers, there are now more known recovered cases (3141) than active cases (3043)in Australia.

I suspect there may be even more recovered cases, because some infected persons probably never had a test.

[Lokasenna]

ORIGINAL: obvert

ORIGINAL: Lokasenna

ORIGINAL: RangerJoe




Do you know how this and the previous post compare to Influenza mortality rates?

Given that ~60,000 people don't die from the flu in less than 6 months: higher.

Also, they don't have complete social containment and distancing during each year's flu season. The flu has an RO (with implied vaccine use) of around 1.3. It's gone down to almost no cases now after this lockdown.

I mean I guess technically he was asking about the rate. Whether he meant the rate of death from influenza in the population at large or the actual infection mortality rate of having the flu, who knows? I assumed the former.

[Lokasenna]

ORIGINAL: MakeeLearn

Federal projections suggest coronavirus infections would increase if stay-at-home orders are lifted at 30 days, NYT report says
April 10, 2020


https://www.cnn.com/2020/04/10/health/u ... index.html


"New federal government projections indicate that coronavirus infections and deaths may dramatically increase if social distancing and other measures are lifted after only 30 days, The New York Times reported on Friday.
The projections, obtained by the Times, were drafted by the Department of Homeland Security and the Department of Health and Human Services and dated April 9. The projections don't indicate when those spikes would take place, the Times reported.

The Times reported that the documents outline three scenarios, including one where no restrictions are imposed and another where 25% of people telework, some social distancing continues, and schools remain closed until the summer months. The third scenario adds a 30-day shelter-in-place to the restrictions in the second scenario.

If stay-at-home orders are lifted after 30 days, report says, there would be a bump in the demand for ventilators and the death toll could reach 200,000, according to the Times. "

Ha, my reaction is "today in 'duh' headlines" [:D]

[MakeeLearn]

US coroanvirus: More than 2,000 US coronavirus deaths were reported in a day. That's likely the peak death toll, expert says
2 hrs ago
https://www.msn.com/en-us/news/us/us-co ... li=BBnb7Kz

"The US recorded at least 2,074 deaths Friday, the largest increase in coronavirus fatalities the country has seen since the beginning of the outbreak."

"That brings the total number of reported deaths to 18,777. More than 501,560 people have tested positive, according to Johns Hopkins University's tally of cases in the US."


"The country likely saw a peak in its daily death toll, according to Dr. Chris Murray, the director of the Institute for Health Metrics and Evaluation at the University of Washington -- who created the model the White House is using to gauge the peak of coronavirus cases."

[Canoerebel]

Once daily mortalities drop to zero, once the medical community has had a chance to rest, and having succeeded in the original mission to flatten the curve (in most places), Americans will be ready to go on the offensive.

There will be legitimate concerns, issues and risks, as noted above and in the press and by credible sources, but we can't remain in our bunkers indefinitely.

From a historical standpoint it'll be interesting to see which leaders lead and how they lead. A majority of advisors (media, professors, leaders of all kind) may call for caution - what amounts (from a WWII context) to invasions on the periphery and to rely on the Army Air Corps to defeat the foe from a distance. That won't be sufficient. At some point we'll have to invade Normandy and go toe-to-toe with the foe in his territory.

From Stephen Ambrose's The Victors (p. 41): "It was 'during those anxious hours' in Gibraltar, [Eisenhower] later wrote...'that I first realized how inexorably and inescapably strain and tension wear away at the leader's endurance, his judgment and his confidence. The pressure becomes more acute because of the duty of a staff constantly to 'present to the commander the worst side of an eventuality.' In this situation, Eisenhower realized, the commander had to 'preserve optimism in himself and in his command. Without confidence, enthusiasm and optimism in the command, victory is scarcely obtainable.'"

When mortality is zero, when the medical community has rested and gathered itself, when the conditions mentioned here yesterday are present, it will be time to open the second front. That's going to happen in May or June.

[JohnDillworth]

we'll have to invade Normandy and go toe-to-toe with the foe in his territory.

Weapons, we will need weapons. And Logistics! What are our supplies? As Stalin says quantity has a quality all its own but it would be foolish to throw bodies at this thing without the proper tools to fight it. From the State level a consensus is forming over what tools we need to go on the offensive. I suspect that groundswell will coalesce into a coherent strategy in the near future. Until then we are approaching August 1942, we need to be at August 1943. Mobilization is underway, but is not yet producing all we need in the quantities that we need. As always, it is a battle of logistics. We used to be great at that sort of thing. We need to be great again.