After emailing with Milo, I was able to determine the issue.  The control configuration in the game had "both" joysticks selected even though my computer only has one joystick.  After changing the option to Joystick 1,  the issue was resolved.

Thank you for the suggestion... I have tried this... When you put the ship into autonav mode the craft operates normally, when you take it back out, it continues to corkscrew.

<t> I just installed this game and the first go around went well... I shut the program down for supper and when I came back, I find that there is a big problem...<br/>
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Whenever I lanuch a mission, the ship goes into an uncontrollable right corkscrew. I can not control the ship with my Saitek ...